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KMID : 0371020160490060349
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Journal of Preventive Medicine and Public Health
2016 Volume.49 No. 6 p.349 ~ p.366
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The Effect of Breastfeeding Duration and Parity on the Risk of Epithelial Ovarian Cancer: A Systematic Review and Meta-analysis
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Sung Ho-Kyung
Ma Seung-Hyun
Choi Ji-Yeob
Hwang Yun-Ji
Ahn Choong-Hyun
Kim Byoung-Gie
Kim Yong-Man
Kim Jae-Weon
Kang Sok-Bom
Kim Jae-Hoon
Kim Tae-Jin
Yoo Keun-Young
Kang Dae-Hee
Park Sue-Kyung
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Abstract
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Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC).
Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs).
Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC.
Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.
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KEYWORD
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Ovarian neoplasms, Parity, Breast feeding, Reproduction, Risk factors, Meta-analysis
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